The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. Should your Week 13 NFL picks include backing the Titans to cover the spread, or are you better off targeting other NFL underdogs like the Eagles (+3) at home against the 49ers? All of the Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 13 NFL picks now.

According to the latest Week 13 NFL odds via the SportsLine consensus, the Titans are one-point underdogs at home. The Titans snapped a three-game losing streak with a 17-10 victory over the Panthers and have won five of their last six meetings against the Colts.

Minshew and the Colts will go for their fourth straight when they visit Derrick Henry and the Tennessee Titans in an AFC South showdown on Sunday. Gardner Minshew led the Colts to another victory last Sunday, Indianapolis' third consecutive win.

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